AGP was functioned as acute phase reactant and binding protein of basic drugs. Levels of plasma alpha-1-acid glycoprotein(AGP) were measured by single radial immunodiffusion in 38 normal controls and 38 chronic schizophrenic patients. We
correlated
the
severity of symptoms and the usefulness of differentiation of subtypes in schizophrenia by using Positive and Negative Syndrome Scale(PANSS) with plasma AGP.
@ES The results were as follows:
@EN 1. The plasma AGP concentration was about 35% higher in samples from chronic schzophrenic patients (83.2±24.9 mg/dl) than the normal controls (61.4±12.0 mg/dl, p<0.001). 9 out of the 38 chronic schizophrenics had shown higher plasma AGP
concentration than the highest levels of the normal controls.
2. In chronic schizophrenic patients, the plasma AGP concentration was not correlated significantly with each score of 30 psychiatric parameters and 4 scales(positive, negative, composite and general psychopathlogy) that were rated by
PANSS(R=0.01-0.28).
3. The plasma AGP concentration was not different significantly among four subtypes of schizophrenics (positive, negative, mixed and netither) that categorized by PANSS(p>0.05).
These results indicate that levels of plasma AGP are useful indicator for differentiating schizophrenia from normal, but these are not useful as a biological marker to correlate with severity of symptoms and categorize subtypes.
|